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D Journal Home (http://www.cdc.gov/ncidod/eid/index.htm) > Volume 13, Number 9–September 2007 (http://www.cdc.gov/ncidod/eid/index.htm) Volume 13, Number 9–September 2007

http://www.cdc.gov/eid/content/13/9/1354.htm


Reduced Sensitivity of Influenza A (H5N1) to Oseltamivir

Jennifer L. McKimm-Breschkin,* http://www.cdc.gov/eid/images/cdc/icon_email.gif (http://www.cdc.gov/eid/content/13/9/1354.htm#comment) Paul W. Selleck,† Tri Bhakti Usman,‡ and Michael A. Johnson†
*CSIRO Molecular and Health Technologies, Parkville, Victoria, Australia; †CSIRO Livestock Industries, Geelong, Victoria, Australia; and ‡Disease Investigation Centre Region IV, Yogyakarta, Indonesia
Suggested citation for this article (http://www.cdc.gov/eid/content/13/9/1354.htm#cit)
Abstract
We tested the neuraminidase drug sensitivity of clade 1 and clade 2 influenza A (H5N1). All viruses demonstrated similar sensitivity to zanamivir, but compared with the 2004 clade 1 viruses, the Cambodian 2005 viruses were 6-fold less sensitive and the Indonesian clade 2 viruses were up to 30-fold less sensitive to oseltamivir.

Two different strains of highly pathogenic avian influenza A (H5N1) have been circulating since 2003. Clade 1 has been found in Vietnam, Thailand, Cambodia, Lao People's Democratic Republic, and Malaysia. Clade 2 subsequently emerged and spread from People's Republic of China to Indonesia, Europe, and Africa in 2004–2005. Because of its systemic availability, oseltamivir is the drug of choice for treating infected persons (1 (http://www.cdc.gov/eid/content/13/9/1354.htm#1)).

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